Genetic lesions in MYC and STAT3 drive oncogenic transcription factor overexpression in plasmablastic lymphoma
Plasmablastic lymphoma mutational profile is undescribed.Here we performed a targeted exonic NGS analysis of 30 plasmablastic lymphoma cases with a B cell lymphoma dedicated panel and FISH for the detection of MYC rearrangements.A complete phenotyping of the neoplastic and microenvironment cell populations was also performed.We have identified an e